Back to Search
Start Over
Probing the benzofuroquinolinium derivative as a potent antibacterial agent through the inhibition of FtsZ activity
- Source :
- Journal of Pharmacological Sciences, Vol 138, Iss 1, Pp 83-85 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- A benzofuroquinolinium derivative that exhibits excellent cell division inhibitory effect was discovered through cell-based screening approach. This compound possesses potent antimicrobial activity against both Gram-positive and Gram-negative bacteria including the drug-resistant strains. In addition, this compound is able to restore MRSA susceptibility to beta-lactam antibiotics. The biochemical results suggest that the compound inhibits bacterial cell division through the disruption of GTPase activity and the polymerization of FtsZ, which is probably the mechanism of antibacterial activity. Keywords: Bacterial resistance, Antibacterial activity, FtsZ inhibitor
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Lactams
Cell division
macromolecular substances
Gram-Positive Bacteria
010402 general chemistry
01 natural sciences
Bacterial cell structure
Polymerization
chemistry.chemical_compound
Bacterial Proteins
Drug Resistance, Bacterial
Gram-Negative Bacteria
FtsZ
Benzofurans
Antibacterial agent
Pharmacology
biology
010405 organic chemistry
Chemistry
Quinolinium Compounds
lcsh:RM1-950
Glycogen Debranching Enzyme System
Antimicrobial
biology.organism_classification
Anti-Bacterial Agents
0104 chemical sciences
Cytoskeletal Proteins
lcsh:Therapeutics. Pharmacology
Biochemistry
biology.protein
Molecular Medicine
Antibacterial activity
Cell Division
Derivative (chemistry)
Bacteria
Subjects
Details
- ISSN :
- 13478613
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....27cd428dc6850fb4dcc70b690779b5e4