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High prevalence of developmental venous anomaly in adult patients with midline thalamic diffuse gliomas
- Source :
- Journal of Clinical Neuroscience. 87:59-65
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective This study aimed to assess the prevalence of developmental venous anomaly (DVA) in patients with thalamic glioma. Furthermore, we explored the association between DVA and some important biomarkers, such as IDH1 mutation, and H3K27M mutation. Patients and Methods Patients who received tumor resection in West China Hospital between August 2009 and October 2017 were enrolled. Propensity score matching was conducted based on a logistic regression model and 1:1 matching for case and control was used to generate a new cohort from patients with meningioma. Chi-square test, t-test, univariate and multivariate analyses were employed to assess the prevalence of DVA in thalamic glioma and meningioma and to identify risk factors associated with DVA. Results Ninety-nine patients with thalamic glioma were enrolled in the current study (male, n = 54; female, n = 45). The mean age was 42.9 ± 15.3 years old. We identified a higher prevalence of DVA in 99 patients with thalamic glioma when compared with 99 patients with meningioma (18.18% vs. 7.07%), which was slightly lower than the prevalence of DVA in glioma reported in previous studies. Furthermore, the distribution of gender, age, and tumor grade in DVA did not reach statistical significance. Chi-square test, univariate and multivariate analyses showed that IDH1 mutation, ATRX mutation, MGMT promoter methylation, p53 mutation, MMP9, EGFR, and Top II positive expression, TERT mutation, and H3K27M mutation were not associated with the development of DVA in thalamic glioma. Conclusion A higher prevalence of DVA was found in thalamic glioma compared with meningioma.
- Subjects :
- Adult
Male
Oncology
China
medicine.medical_specialty
Multivariate analysis
Logistic regression
Meningioma
Young Adult
03 medical and health sciences
0302 clinical medicine
Thalamus
Physiology (medical)
Internal medicine
Statistical significance
Glioma
Meningeal Neoplasms
Prevalence
medicine
Humans
neoplasms
ATRX
Brain Neoplasms
business.industry
General Medicine
Middle Aged
medicine.disease
nervous system diseases
Neurology
030220 oncology & carcinogenesis
Mutation
Propensity score matching
Cohort
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09675868
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....27bcc89b5c02bb6569731419517b5edb