Back to Search
Start Over
Evolution of Digestive Enzymes and RNASE1 Provides Insights into Dietary Switch of Cetaceans
- Source :
- Molecular Biology and Evolution
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Although cetaceans (whales, porpoises, and dolphins) have multi-chambered stomachs, feeding habits of modern cetaceans have dramatically changed from herbivorous to carnivorous. However, the genetic basis underlying this dietary switch remains unexplored. Here, we present the first systematic investigation of 10 digestive enzymes genes (i.e., CYP7A1, CTRC, LIPC, LIPF, PNLIP, PGC, PRSS1, SI, SLC5A1, and TMPRSS15) of representative cetaceans, and the evolutionary trajectory of RNASE1 in cetartiodactylans. Positive selections were detected with proteinases (i.e., CTRC, PRSS1, and TMPRSS15) and lipases (i.e., CYP7A1, LIPF, and PNLIP) suggesting that cetaceans have evolved an enhanced digestion capacity for proteins and lipids, the major nutritional components of their prey (fishes and invertebrates). In addition, it was found that RNASE1 gene duplicated after the cetartiodactylan speciation and two independent gene duplication events took place in Camelidae and Ruminantia. Positive selection was detected with RNASE1 of Camelidae and Bovidae, suggesting enhanced digestive efficiency in the ruminants. Remarkably, even though the ancestors of cetaceans were terrestrial artiodactyls that are herbivorous, modern cetaceans lost the pancreatic RNASE1 copy with digestive function, which is in accordance with the dietary change from herbivorous to carnivorous. In sum, this is the first study that provides new insights into the evolutionary mechanism of dietary switch in cetaceans.
- Subjects :
- 0301 basic medicine
Dolphins
media_common.quotation_subject
dietary switch
Zoology
Bovidae
Biology
Receptors, Odorant
Predation
cetaceans
Evolution, Molecular
03 medical and health sciences
Sodium-Glucose Transporter 1
positive selection
Gene Duplication
evolution
Gene duplication
Genetics
Animals
Chymotrypsin
Trypsin
Selection, Genetic
Cholesterol 7-alpha-Hydroxylase
Molecular Biology
Gene
Discoveries
Phylogeny
Ecology, Evolution, Behavior and Systematics
RNASE1
media_common
Whales
Feeding Behavior
Lipase
Ribonuclease, Pancreatic
biology.organism_classification
Speciation
030104 developmental biology
digestive enzymes
Cetacea
Digestion
Function (biology)
Subjects
Details
- ISSN :
- 15371719 and 07374038
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Molecular Biology and Evolution
- Accession number :
- edsair.doi.dedup.....27b87d2e0b1bde6237da800c5a887447