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Overexpression of BAMBI and SMAD7 impacts prognosis of acute myeloid leukemia patients: A potential TERT non-canonical role
- Source :
- Cancer Biomarkers. 31:47-58
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- BACKGROUND: Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and mothers against decapentaplegic homolog 7 (SMAD7) are important transforming growth factor-β (TGF-β) signaling antagonists, however their roles in acute myeloid leukemia (AML) remains unclear. Telomerase reverse transcriptase (TERT) may be involved in regulating BAMBI and SMAD7 expressions; a role beyond telomeres that is not clinically validated yet. OBJECTIVE: In this study, we examined the expression levels and prognostic values of BAMBI, SMAD7 and TERT and their association with AML patients’ outcomes. METHODS: Blood samples were collected from 74 de-novo AML patients and 16 controls. Real-time quantitative PCR (qRT-PCR) was performed to analyze BAMBI, SMAD7 and TERT expressions. RESULTS: BAMBI and SMAD7 expression in AML were significantly upregulated versus controls (p< 0.05). BAMBI, SMAD7 and TERT levels were significantly correlated together (p< 0.001). Kaplan-Meier analysis indicated that patients with high BAMBI, SMAD7 and TERT expression levels had markedly shorter event free survival (EFS) and overall survival (OS) time (p< 0.01). Furthermore, multivariate analysis revealed that only high BAMBI expression was an independent risk factor for OS (p= 0.001). CONCLUSIONS: BAMBI is a novel biomarker in predicting prognosis in AML patients. Moreover, a potential interplay is found between BAMBI, SMAD7 and TERT in AML pathogenies.
- Subjects :
- Male
Cancer Research
Smad7 Protein
03 medical and health sciences
0302 clinical medicine
Mothers against decapentaplegic homolog 7
Genetics
Humans
Medicine
Telomerase reverse transcriptase
Telomerase
030304 developmental biology
0303 health sciences
integumentary system
business.industry
Membrane Proteins
Myeloid leukemia
General Medicine
Middle Aged
Prognosis
Healthy Volunteers
Telomere
Leukemia, Myeloid, Acute
Real-time polymerase chain reaction
Oncology
030220 oncology & carcinogenesis
Cancer research
Biomarker (medicine)
Female
BAMBI
business
Transforming growth factor
Subjects
Details
- ISSN :
- 18758592 and 15740153
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Cancer Biomarkers
- Accession number :
- edsair.doi.dedup.....27b37f8d46a88f61ba034eb964948805