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The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria
- Source :
- Annu Rev Microbiol
- Publication Year :
- 2015
- Publisher :
- Annual Reviews, 2015.
-
Abstract
- The mechanism by which the cholesterol-dependent cytolysins (CDCs) assemble their giant β-barrel pore in cholesterol-rich membranes has been the subject of intense study in the past two decades. A combination of structural, biophysical, and biochemical analyses has revealed deep insights into the series of complex and highly choreographed secondary and tertiary structural transitions that the CDCs undergo to assemble their β-barrel pore in eukaryotic membranes. Our knowledge of the molecular details of these dramatic structural changes in CDCs has transformed our understanding of how giant pore complexes are assembled and has been critical to our understanding of the mechanisms of other important classes of pore-forming toxins and proteins across the kingdoms of life. Finally, there are tantalizing hints that the CDC pore-forming mechanism is more sophisticated than previously imagined and that some CDCs are employed in pore-independent processes.
- Subjects :
- Models, Molecular
Pore Forming Cytotoxic Proteins
Microbial toxins
Cytotoxins
Bacterial Toxins
Cell Membrane
Biology
Gram-Positive Bacteria
Microbiology
Protein Structure, Secondary
Article
Cell membrane
Intermedilysin
Cholesterol
medicine.anatomical_structure
Membrane
medicine
Biophysics
Humans
Perfringolysin O
Subjects
Details
- ISSN :
- 15453251 and 00664227
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Annual Review of Microbiology
- Accession number :
- edsair.doi.dedup.....27b2d43224d593eeeecdd568a3acd81d