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ACTH occurrence in teleosts supramedullary neuron clusters: a neuron-glial common language?
- Publication Year :
- 2003
-
Abstract
- The cross-talk between neurons and glia is receiving increased attention because of its potential role in information processing in the nervous system. We choose the cluster of supramedullary neurons (SN) and glial cells of pufferfish as a suitable model for studying neuron-glial interactions, identifying the implicated cell types and the signalling involved. In particular, among proopiomelanocortin (POMC)-derived peptides, adrenocorticotrope hormone (ACTH)-immunopositivity was found both in SN and in microglial cells. The present results for the first time show the presence of ACTH in microglia of a vertebrate. The role of ACTH is discussed, including its possible neuroprotective function. Moreover, SN immunoreactivity supports the idea that ACTH participates in neurotransmission and/or neuromodulation. In addition to these possible functions, the hypothesis is put forward that ACTH represents a common language by which neurons and glial cells communicate with each other.
- Subjects :
- Nervous system
endocrine system
medicine.medical_specialty
Cell type
Pro-Opiomelanocortin
Cell Communication
Adrenocorticotropic hormone
Biology
Neurotransmission
Endocrinology
Adrenocorticotropic Hormone
Neuromodulation
Internal medicine
medicine
Animals
Cells, Cultured
Cell Aggregation
Neurons
Medulla Oblongata
Histocytochemistry
Tetraodontiformes
Brain
Immunohistochemistry
ACTH
Microglia
Supramedullary neurons
Tetraodon fluviatilis teleost
Peptide Fragments
Cell aggregation
medicine.anatomical_structure
nervous system
Neuroglia
Animal Science and Zoology
Neuron
Neuroscience
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....27b0aa2dc44bfb30ad91b66ec04a1a01