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Prognostic value of left ventricular dyssynchrony evaluated by gated myocardial perfusion imaging in patients with chronic kidney disease and normal perfusion defect scores
- Source :
- Journal of Nuclear Cardiology. 26:288-297
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- This study aimed to investigate whether indices of left ventricular (LV) dyssynchrony by gated myocardial perfusion SPECT (GMPS) could be useful to predict prognosis in chronic kidney disease (CKD) patients with normal perfusion defect scores. One hundred and sixty-seven CKD patients with normal perfusion defect scores on adenosine-stress 201Tl GMPS and no previous history of overt heart diseases were enrolled. Phase standard deviation (PSD) and bandwidth (BW) were automatically calculated from GMPS. The major adverse cardiac events (MACEs) for a mean of 560 days were defined as sudden cardiac death, fatal arrhythmias, and acute coronary syndrome requiring urgent coronary revascularization. Patients were divided into two groups according to the presence or absence of MACEs. The MACEs occurred in 12 patients (7.1%). Patients who experienced MACEs showed significantly higher PSD and wider BW than those who did not. In the Kaplan-Meier event-free survival analysis, cardiac event rate was significantly higher in the high-PSD and wide-BW group (n = 81) than in the low-PSD and narrow-BW group (n = 71) (P = .002). The multivariate regression analysis revealed that the PSD was associated with MACEs (odds ratio 1.33, 95% confidence interval 1.05-1.69, P = .01). The LV dyssynchrony indices from GMPS may be novel prognostic predictors in CKD patients with normal perfusion defect scores.
- Subjects :
- Male
Acute coronary syndrome
medicine.medical_specialty
Heart Ventricles
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Sudden cardiac death
Ventricular Dysfunction, Left
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
Ventricular dyssynchrony
Aged
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
medicine.diagnostic_test
business.industry
Myocardial Perfusion Imaging
Odds ratio
Middle Aged
Prognosis
medicine.disease
Confidence interval
Thallium Radioisotopes
Treatment Outcome
Cardiology
Kidney Failure, Chronic
Female
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Cardiology and Cardiovascular Medicine
business
Perfusion
Kidney disease
Subjects
Details
- ISSN :
- 15326551 and 10713581
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Cardiology
- Accession number :
- edsair.doi.dedup.....279bffab629be5e1b43ea96bfa727e48