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Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population
- Source :
- European journal of clinical pharmacology. 58(6)
- Publication Year :
- 2002
-
Abstract
- Objective. The goal of this study was to determine the frequencies of allelic variants of CYP2B6 and CYP3A5 in the Japanese population. Methods. Genotyping of CYP2B6(*2, *3, *4, *5, *6, and *7) and CYP3A5 (*2, *3, *4, *5, and *6) was carried out in 265 unrelated Japanese subjects by polymerase chain reaction (PCR), restriction fragment length polymorphism and allele-specific, real-time PCR assays. Results. Allele frequencies for CYP2B6*2, *3, *4, *5, *6, and *7 in 256 Japanese subjects were 0.047, 0, 0.093, 0.011, 0.164, and 0, respectively. Ethnic variation in allele frequencies relative to that in Caucasian subjects was observed for CYP2B6*4 (0.093 vs 0.040), *5 (0.011 vs 0.109), *6 (0.164 vs 0.256), and *7 (0 vs 0.030). Allele frequencies for CYP3A5*2, *3, *4, *5, and *6 in 265 Japanese subjects were 0, 0.740, 0, 0.004, and 0, respectively. The frequency of the CYP3A5*1 allele is 2.8 times higher in Japanese than in Caucasians. Conclusions. Our results contribute to a better understanding of the molecular basis of ethnic differences in drug response, which may help to improve individualization of drug therapy and offer a preliminary basis for more rational use of drugs that are substrates for CYP2B6 and CYP3A5 in the Japanese population.
- Subjects :
- Male
Genotype
Biology
Polymerase Chain Reaction
Cytochrome P-450 Enzyme System
Gene Frequency
Japan
Cytochrome P-450 CYP3A
Humans
Pharmacology (medical)
Allele
Allele frequency
Genotyping
Pharmacology
Genetics
Oxidoreductases, N-Demethylating
General Medicine
Genotype frequency
Minor allele frequency
Cytochrome P-450 CYP2B6
Female
Aryl Hydrocarbon Hydroxylases
Restriction fragment length polymorphism
Pharmacogenetics
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 00316970
- Volume :
- 58
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European journal of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....278c377b3ddda43b54995a3d9a122e02