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Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection
- Source :
- Advanced Materials
-
Abstract
- A stacked plasmonic nanowell-nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal-to-background (S/B) ratio for single-molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single-DNA sensing.
- Subjects :
- 0301 basic medicine
Background fluorescence
Materials science
Light
Nanotechnology
Biosensing Techniques
02 engineering and technology
law.invention
Nanopores
03 medical and health sciences
law
Molecule
General Materials Science
Plasmon
Mechanical Engineering
DNA
021001 nanoscience & nanotechnology
Laser
Nanopore
Fluorescence intensity
030104 developmental biology
Mechanics of Materials
0210 nano-technology
Biosensor
Excitation
Subjects
Details
- Language :
- English
- ISSN :
- 09359648
- Volume :
- 29
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Advanced Materials
- Accession number :
- edsair.doi.dedup.....2762c3b7e2642d4e204a630dcf0ef629
- Full Text :
- https://doi.org/10.1002/adma.201605442