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Naming Genes for Dystonia: DYT-z or Ditzy?

Authors :
Jinnah, H. A.
Mencacci, Niccolo E.
Source :
Tremor and Other Hyperkinetic Movements, Vol 9, Iss 0, Pp 1-6 (2019), Tremor and Other Hyperkinetic Movements
Publication Year :
2019
Publisher :
Ubiquity Press, 2019.

Abstract

Dystonias are a clinically and etiologically diverse group of disorders. Numerous genes have now been associated with different dystonia syndromes, and multiple strategies have been proposed for how these genes should be lumped and split into meaningful categories. The traditional approach has been based on the Human Genome Organization’s plan for naming genetic loci for all disorders. For dystonia this involves a DYT prefix followed by a number (e.g., DYT1, DYT2, DYT3, etc.). A more recently proposed approach involves assigning multiple prefixes according to the main elements of the phenotype (e.g., DYT, PARK, CHOR, TREM, etc.) followed by the name of the responsible gene. This article describes these nomenclature systems and summarizes some of their limitations. We focus on dystonia as an example, although the concepts may be applied to all movement disorders. Keywords: Dystonia, nomenclature, gene, locus, mutation, genetic variant Citation: Mencacci NE, Jinnah HA. Naming Genes for Dystonia: DYT-z or Ditzy? Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.710<br />Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements

Details

Language :
English
ISSN :
21608288
Volume :
9
Database :
OpenAIRE
Journal :
Tremor and Other Hyperkinetic Movements
Accession number :
edsair.doi.dedup.....2760879ef54e1d5238d7d8e3655dc3e0