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Antibodies against endogenous retroviruses promote lung cancer immunotherapy
- Publication Year :
- 2023
- Publisher :
- The Francis Crick Institute, 2023.
-
Abstract
- B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive1,2. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma3. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
- Subjects :
- Model organisms
Lung Neoplasms
Immunology
Gene Expression
Adenocarcinoma of Lung
Infectious Disease
Antibodies
Cohort Studies
Mice
Signalling & Oncogenes
Ecology,Evolution & Ethology
Carcinoma, Non-Small-Cell Lung
Tumor Microenvironment
Animals
Humans
Lung
Computational & Systems Biology
Chemical Biology & High Throughput
B-Lymphocytes
Human Biology & Physiology
Stem Cells
FOS: Clinical medicine
Endogenous Retroviruses
Genome Integrity & Repair
Cell Biology
Tumour Biology
Disease Models, Animal
Cell Cycle & Chromosomes
Immunotherapy
Genetics & Genomics
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....27515837fa8cee0accd7c7f1460cb13f
- Full Text :
- https://doi.org/10.25418/crick.22665394