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Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice
- Publication Year :
- 2008
- Publisher :
- National Academy of Sciences, 2008.
-
Abstract
- IL-10-secreting regulatory T cell lines specific to glatiramer acetate [poly(Y,E,A,K)n] or poly(Y,F,A,K)n have been established from the enlarged spleen and lymph nodes that result from copolymer treatment of SJL mice in which experimental autoimmune encephalomyelitis was induced by PLP139-151. These CD4+CD25+T cell lines secrete high levels of IL-10 and IL-13 but only small amounts of IL-4 and virtually no TGF-β, IL-17, IL-6, IFN-γ, or TNF-α. Their phenotypes are particularly characterized by the absence of Foxp3 and the presence of two TNFR family members, CD30 and GITR. The lines proliferated specifically to the immunizing copolymers but were autoantigen-nonspecific, in that the same T cell line could suppress autoimmunity induced by three different autoantigens in SJL mice, i.e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression.
- Subjects :
- Adoptive cell transfer
Encephalomyelitis, Autoimmune, Experimental
Regulatory T cell
T cell
Receptors, Antigen, T-Cell
Cell Separation
Biology
medicine.disease_cause
T-Lymphocytes, Regulatory
Autoimmunity
Cell Line
Mice
medicine
Animals
IL-2 receptor
Amino Acids
Cell Proliferation
Multidisciplinary
Experimental autoimmune encephalomyelitis
FOXP3
Forkhead Transcription Factors
Bystander Effect
Biological Sciences
medicine.disease
Molecular biology
Adoptive Transfer
Interleukin-10
medicine.anatomical_structure
Phenotype
Interleukin 13
Immunology
Cattle
Peptides
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2744c147b90f8f9f970c8af9d0113951