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Physical activity and risks of breast and colorectal cancer : a Mendelian randomisation analysis
- Source :
- Nature Communications, 11(1). Nature Publishing Group, Nature Communications, 11(1), Papadimitriou, N, Dimou, N L, Tsilidis, K K, Banbury, B, Martin, R M, Lewis, S J, Kazmi, N, Robinson, T M, Albanes, D, Aleksandrova, K, Berndt, S I, Bishop, T D, Brenner, H, Buchanan, D D, Bueno-de-Mesquita, H B, Campbell, P T, Castellví-Bel, S, Chan, A T, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, J C, Gallinger, S, Giles, G G, Giovannucci, E, Gruber, S B, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, T A, Hoffmeister, M, Hopper, J L, Hsu, L, Huerta, J-M, Huyghe, J R, Jenkins, M A, Keku, T O, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C, Li, L, Lindblom, A, Lindor, N M, Lynch, B, Markowitz, S, Masala, G, May, A, Milne, R L, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P, Offit, K, Perduca, V, Pharoah, P, Platz, E A, Potter, J D, Rennert, G, Riboli, E, Sanchez, M-J, Schmit, S L, Schoen, R E, Severi, G, Sieri, S, Slattery, M L, Song, M, Tangen, C M, Thibodeau, S, Travis, R C, Trichopoulou, A, Ulrich, C M, van Duijnhoven, F J, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M, Wu, A H, Peters, U, Gunter, M J & Murphy, N 2020, ' Physical activity and risks of breast and colorectal cancer : A Mendelian randomization analysis ', Nature Communications, vol. 11, 597 (2020) . https://doi.org/10.1038/s41467-020-14389-8, Nature Communications, Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14389-8⟩, Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020), Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR), Dipòsit Digital de la UB, Universidad de Barcelona, Nature Communications 11 (2020) 1, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Papadimitriou, N, Dimou, N, Tsilidis, K K, Banbury, B, Martin, R M, Lewis, S J, Kazmi, N, Robinson, T M, Albanes, D, Aleksandrova, K, Berndt, S I, Timothy Bishop, D, Brenner, H, Buchanan, D D, Bueno-de-Mesquita, B, Campbell, P T, Castellví-Bel, S, Chan, A T, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, J C, Gallinger, S J, Giles, G G, Giovannucci, E, Gruber, S B, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, T A, Hoffmeister, M, Hopper, J L, Hsu, L, María Huerta, J, Huyghe, J R, Jenkins, M A, Keku, T O, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C I, Li, L, Lindblom, A, Lindor, N M, Lynch, B, Markowitz, S D, Masala, G, May, A M, Milne, R, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P A, Offit, K, Perduca, V, Pharoah, P D P, Platz, E A, Potter, J D, Rennert, G, Riboli, E, Sánchez, M-J, Schmit, S L, Schoen, R E, Severi, G, Sieri, S, Slattery, M L, Song, M, Tangen, C M, Thibodeau, S N, Travis, R C, Trichopoulou, A, Ulrich, C M, van Duijnhoven, F J B, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M O, Wu, A H, Peters, U, Gunter, M J & Murphy, N 2020, ' Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis ', Nature Communications, vol. 11, 597 . https://doi.org/10.1038/s41467-020-14389-8
- Publication Year :
- 2020
-
Abstract
- Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.<br />United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI)<br />International Agency for Research on Cancer<br />Cancer Research UK C18281/A19169<br />National Institute for Health Research (NIHR)
- Subjects :
- Oncology
Epidemiology
Colorectal cancer
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Accelerometry [Medical Subject Headings]
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology::Mendelian Randomization Analysis [Medical Subject Headings]
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
0302 clinical medicine
Breast cancer
Epidemiology of cancer
Accelerometry
Odds Ratio
lcsh:Science
skin and connective tissue diseases
Cancer genetics
ComputingMilieux_MISCELLANEOUS
Cancer
0303 health sciences
Biobank
3. Good health
030220 oncology & carcinogenesis
ICEP
Factores de riesgo
medicine.medical_specialty
Science
631/67/2324
Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colorectal Neoplasms, Hereditary Nonpolyposis [Medical Subject Headings]
Breast Neoplasms/genetics
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
SDG 3 - Good Health and Well-being
Càncer colorectal
Anthropology, Education, Sociology and Social Phenomena::Human Activities::Exercise [Medical Subject Headings]
Humans
Epidemiologia
Exercise
VLAG
Cancer och onkologi
45
631/67/1347
Odds ratio
Mendelian Randomization Analysis
medicine.disease
Colorectal Neoplasms/genetics
030104 developmental biology
Analyses
Risk factors
Check Tags::Female [Medical Subject Headings]
Cancer and Oncology
lcsh:Q
Breast neoplasms
0301 basic medicine
631/67/1504/1885
Nutrition and Disease
General Physics and Astronomy
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]
Risk Factors
Neoplasias colorrectales
Voeding en Ziekte
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio [Medical Subject Headings]
Multidisciplinary
article
Public Health, Global Health, Social Medicine and Epidemiology
Polymorphism, Single Nucleotide/genetics
Ejercicio físico
Neoplasias de la mama
Female
Colorectal Neoplasms
631/67
141
Breast Neoplasms
45/23
Polymorphism, Single Nucleotide
Colorectal neoplasms
Càncer de mama
Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings]
Cancer epidemiology
631/67/68
Internal medicine
Mendelian randomization
medicine
Journal Article
Life Science
Genetic Predisposition to Disease
Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings]
030304 developmental biology
Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings]
business.industry
General Chemistry
Physical fitness
Confidence interval
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Condició física
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, 11(1). Nature Publishing Group, Nature Communications, 11(1), Papadimitriou, N, Dimou, N L, Tsilidis, K K, Banbury, B, Martin, R M, Lewis, S J, Kazmi, N, Robinson, T M, Albanes, D, Aleksandrova, K, Berndt, S I, Bishop, T D, Brenner, H, Buchanan, D D, Bueno-de-Mesquita, H B, Campbell, P T, Castellví-Bel, S, Chan, A T, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, J C, Gallinger, S, Giles, G G, Giovannucci, E, Gruber, S B, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, T A, Hoffmeister, M, Hopper, J L, Hsu, L, Huerta, J-M, Huyghe, J R, Jenkins, M A, Keku, T O, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C, Li, L, Lindblom, A, Lindor, N M, Lynch, B, Markowitz, S, Masala, G, May, A, Milne, R L, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P, Offit, K, Perduca, V, Pharoah, P, Platz, E A, Potter, J D, Rennert, G, Riboli, E, Sanchez, M-J, Schmit, S L, Schoen, R E, Severi, G, Sieri, S, Slattery, M L, Song, M, Tangen, C M, Thibodeau, S, Travis, R C, Trichopoulou, A, Ulrich, C M, van Duijnhoven, F J, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M, Wu, A H, Peters, U, Gunter, M J & Murphy, N 2020, ' Physical activity and risks of breast and colorectal cancer : A Mendelian randomization analysis ', Nature Communications, vol. 11, 597 (2020) . https://doi.org/10.1038/s41467-020-14389-8, Nature Communications, Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14389-8⟩, Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020), Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR), Dipòsit Digital de la UB, Universidad de Barcelona, Nature Communications 11 (2020) 1, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Papadimitriou, N, Dimou, N, Tsilidis, K K, Banbury, B, Martin, R M, Lewis, S J, Kazmi, N, Robinson, T M, Albanes, D, Aleksandrova, K, Berndt, S I, Timothy Bishop, D, Brenner, H, Buchanan, D D, Bueno-de-Mesquita, B, Campbell, P T, Castellví-Bel, S, Chan, A T, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, J C, Gallinger, S J, Giles, G G, Giovannucci, E, Gruber, S B, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, T A, Hoffmeister, M, Hopper, J L, Hsu, L, María Huerta, J, Huyghe, J R, Jenkins, M A, Keku, T O, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C I, Li, L, Lindblom, A, Lindor, N M, Lynch, B, Markowitz, S D, Masala, G, May, A M, Milne, R, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P A, Offit, K, Perduca, V, Pharoah, P D P, Platz, E A, Potter, J D, Rennert, G, Riboli, E, Sánchez, M-J, Schmit, S L, Schoen, R E, Severi, G, Sieri, S, Slattery, M L, Song, M, Tangen, C M, Thibodeau, S N, Travis, R C, Trichopoulou, A, Ulrich, C M, van Duijnhoven, F J B, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M O, Wu, A H, Peters, U, Gunter, M J & Murphy, N 2020, ' Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis ', Nature Communications, vol. 11, 597 . https://doi.org/10.1038/s41467-020-14389-8
- Accession number :
- edsair.doi.dedup.....2739b61a9bf914f499b34365637dbdbf