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Growth hormone and segmental growth in survivors of head and neck embryonal rhabdomyosarcoma
- Publication Year :
- 2001
- Publisher :
- BMJ Group, 2001.
-
Abstract
- AIMS—To assess the impact of treatment for embryonal rhabdomyosarcoma on spinal growth and limb length and examine the response of these parameters to growth hormone (GH) treatment. METHODS—We conducted a retrospective case note review of 17 survivors of head and neck rhabdomyosarcoma followed up at a single institution. All children had been treated with chemotherapy and local radiotherapy. Growth velocity, height, sitting height, and subischial limb length SDS scores were analysed. RESULTS—Growth failure secondary to isolated GH deficiency (GHD) developed in 7/17 patients. GHD occurred at a median (range) of 3.4(1.3-9.9) years after radiotherapy tumour doses of 46 (40-50) Gy. Growth velocity, height, and subischial limb length SDS were significantly reduced in the GHD group and improved with GH therapy. CONCLUSIONS—GH treatment resulted in a significant improvement in sitting height SDS. We discuss the unexpected improvement in spinal growth in survivors with GHD.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
medicine
Humans
Rhabdomyosarcoma, Embryonal
Leg Bones
Survivors
Rhabdomyosarcoma
Child
Rachis
Growth Disorders
Retrospective Studies
Chemotherapy
business.industry
Infant
Retrospective cohort study
medicine.disease
General and Acute Paediatrics
Body Height
Spine
Surgery
Radiation therapy
El Niño
Head and Neck Neoplasms
Child, Preschool
Growth Hormone
Pediatrics, Perinatology and Child Health
Female
Embryonal rhabdomyosarcoma
Sarcoma
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2737ff0006973f10da8d450d34e8149c