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Altona Prognostic Index: A New Prognostic Index for ER-Positive and Her2-Negative Breast Cancer of No Special Type
- Source :
- Cancers, Vol 13, Iss 3799, p 3799 (2021), Cancers, Volume 13, Issue 15
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Breast cancer is a heterogeneous disease representing a number of different histopathologic and molecular types which should be taken into consideration if prognostic or predictive models are to be developed. The aim of the present study was to demonstrate the validity of the long-known Nottingham prognostic index (NPI) in a large retrospective study (n = 6654 women with a first primary unilateral and unifocal invasive breast cancer diagnosed and treated between April 1996 and October 2018<br />median follow-up time of breast cancer cases was 15.5 years [14.9–16.8]) from a single pathological institution. Furthermore, it was intended to develop an even superior risk stratification model considering an additional variable, namely the patient’s age at the time of diagnosis. Heterogeneity of these cases was addressed by focusing on estrogen receptor-positive as well as Her2-negative cases and taking the WHO-defined different tumor types into account. Calculating progression free survival Cox-regression and CART-analysis revealed significantly superior iAUC as well as concordance values in comparison to the NPI based stratification, leading to an alternative, namely the Altona prognostic index (API). The importance of the histopathological tumor type was corroborated by the fact that when calculated separately and in contrast to the most frequent so-called “No Special Type” (NST) carcinomas, neither NPI nor API could show valid prognostic stratification.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Index (economics)
Concordance
Disease
Article
03 medical and health sciences
breast cancer
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Progression-free survival
Pathological
histological types of neoplasms
RC254-282
progression free survival
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Retrospective cohort study
medicine.disease
unilateral breast cancer
humanities
030104 developmental biology
030220 oncology & carcinogenesis
Nottingham Prognostic Index
prognosis
business
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....2736ea3f95f435c45489e5de7838d272