Back to Search
Start Over
Dietary Xylitol Retards the Ovariectomy-Induced Increase of Bone Turnover in Rats
- Source :
- Calcified Tissue International. 60:462-466
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- The effects of 10% dietary xylitol supplementation in ovariectomized rats were studied on the degradation of bone organic and inorganic structures. The osseal concentrations of hydroxyproline, pyridinoline, and deoxypyridinoline were analyzed by high-performance liquid chromatography. Bone resorption was measured in [3H]tetracycline-prelabeled rats by urinary excretion of 3H, and by the amount of 3H preserved in bone. Bone trabeculation was measured by a computer image analyzer from sections stained by the method of von Kossa. The amount of collagen in bone organic fraction was lower in ovariectomized rats as compared with the sham-operated controls. This most likely is partly a consequence of an increased resorption, and partly a consequence of a higher proportion of immature periosteal bone in the ovariectomized animals, leading to a higher ratio of noncollagenous protein to collagen. The number of pyridinium crosslinks was lower in proportion, indicating no selective changes in the structure of collagen. Dietary xylitol significantly retarded the ovariectomy-associated decrease in the relative amount of collagen and the number of its mature crosslinks. Ovariectomy doubled the excretion of 3H and caused a significant decrease in the amount of 3H preserved in bone; both these changes were significantly retarded by the 10% dietary xylitol supplementation. Ovariectomy significantly decreased the volume of bone trabeculae, but this effect was also significantly inhibited by the xylitol supplementation in the diet. In conclusion, these findings suggest a dietary xylitol-induced normalizing effect on the rate of bone turnover in ovariectomized rats.
- Subjects :
- Deoxypyridinoline
medicine.medical_specialty
Ovariectomy
Endocrinology, Diabetes and Metabolism
Weight Gain
Xylitol
Bone and Bones
Bone resorption
Bone remodeling
Rats, Sprague-Dawley
chemistry.chemical_compound
Hydroxyproline
Endocrinology
Internal medicine
medicine
Animals
Orthopedics and Sports Medicine
Bone Resorption
Bone Development
Pyridinoline
Tibia
Chemistry
Tetracycline
Rats
Resorption
Food, Fortified
Ovariectomized rat
Female
Collagen
Biomarkers
Subjects
Details
- ISSN :
- 14320827 and 0171967X
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Calcified Tissue International
- Accession number :
- edsair.doi.dedup.....271f7a98a31436ab15fe1410f779bb11