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Comparative analysis of Achilles tendon healing outcomes after open tenotomy versus percutaneous tenotomy: An experimental study in rats
- Source :
- Journal of Orthopaedic Research. 40:1446-1456
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- There is growing interest in conservative treatment of Achilles tendon rupture. However, the majority of experimental studies of Achilles tendon have been performed by open tenotomy. More appropriate model of conservative treatment of Achilles tendon rupture is required. We performed experimental study to evaluate whether outcomes differ between open tenotomy and percutaneous tenotomy of the Achilles tendon in rats. The Achilles tendons of 48 rats were transected. The animals were divided into two groups according to surgical technique: open tenotomy or microscopy-assisted percutaneous tenotomy. After 1, 2, and 4 weeks, functional, biomechanical, and histological analyses were performed. Western blot was performed for quantitative molecular analysis at 1 week. The Achilles functional index was superior in the percutaneous tenotomy group, compared with the open tenotomy group, at 1 week. The cross-sectional area was significantly larger in the percutaneous tenotomy group than in the open tenotomy group at 4 weeks. Relative to the native tendons, load to failure and stiffness yielded comparable results at 2 weeks in the percutaneous tenotomy group and at 4 weeks in the open tenotomy group. The histological score was significantly better in the percutaneous tenotomy group than in the open tenotomy group at 1 week. At 1week, interleukin-1β expression in the open tenotomy group was higher than in the percutaneous tenotomy group. In summary, Achilles tendon healing was substantially affected by the tenotomy method. We presume that our percutaneous tenotomy method might constitute a useful experimental animal model for conservative treatment of Achilles tendon rupture. This article is protected by copyright. All rights reserved.
- Subjects :
- Rupture
Wound Healing
medicine.medical_specialty
Achilles tendon
Percutaneous
business.industry
medicine.medical_treatment
Tenotomy
Achilles Tendon
Rats
Surgery
Molecular analysis
Conservative treatment
medicine.anatomical_structure
Tendon Injuries
Orthopedic surgery
Load to failure
Animals
Medicine
Orthopedics and Sports Medicine
Ankle Injuries
Achilles tendon rupture
medicine.symptom
business
Subjects
Details
- ISSN :
- 1554527X and 07360266
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Orthopaedic Research
- Accession number :
- edsair.doi.dedup.....271b6eb75ced20697c59eb6b97e9d779