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Chemotherapy for advanced thymic carcinoma: clinical response to cisplatin, doxorubicin, vincristine, and cyclophosphamide (ADOC chemotherapy)
- Source :
- American journal of clinical oncology. 25(3)
- Publication Year :
- 2002
-
Abstract
- The role of systemic chemotherapy and optimal regimen in thymic carcinoma remains uncertain. We evaluated the clinical responsiveness of ADOC (cisplatin, doxorubicin, vincristine, and cyclophosphamide) chemotherapy for advanced thymic carcinoma that have distant metastatic or unresectable lesions. From 1996 to 2000, we treated eight cases of thymic carcinoma. According to the classification by Masaoka et al., the clinical stage in one case was IVa, whereas the others were IVb. Histologic subtypes were as follows: four cases were squamous cell carcinoma, two cases were undifferentiated, and two were small-cell carcinoma. All patients received 50 mg/m2 of cisplatin and 40 mg/m2 of doxorubicin intravenously on day 1, 0.6 mg/m2 of vincristine intravenously on day 3, and 700 mg/m2 of cyclophosphamide intravenously on day 4, ADOC regimen, respectively, at 3- to 4-week intervals. Six patients obtained a partial response after ADOC chemotherapy and the overall clinical response rate was 75%. There were no life-threatening side effects noted. Cisplatin plus VP-16 chemotherapy (PVP) was performed in three cases before the ADOC regimen, but PVP chemotherapy did not show beneficial effects in two patients. Median survival time was 19 months. ADOC chemotherapy appears to have significant activity against thymic carcinoma.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Vincristine
Cyclophosphamide
medicine.medical_treatment
chemistry.chemical_compound
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Carcinoma
Medicine
Humans
Doxorubicin
Thymic carcinoma
Aged
Neoplasm Staging
Chemotherapy
business.industry
Remission Induction
Thymus Neoplasms
Middle Aged
medicine.disease
Nitrogen mustard
Surgery
Survival Rate
Regimen
chemistry
Female
Cisplatin
business
medicine.drug
Subjects
Details
- ISSN :
- 02773732
- Volume :
- 25
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....26e74528064c54f15d5b1c2ecbff3a5b