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Safety evaluation of chitosan and chitosan acid salts from Panurilus argus lobster
- Source :
- International Journal of Biological Macromolecules. 72:1343-1350
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Chitosan is a natural polymer with excellent properties such as biocompatibility, biodegradability, non-toxicity and adsorptive abilities. We obtained chitosan derived from Panurilus argus lobster shell and its lactate and acetate salts to introduce in pharmaceutical industry. We examined the single and repeated dose toxicity of chitosan and its lactate and acetate salts. Single oral doses of 2000 mg/kg were well tolerated for all three materials. In the repeat dose tests, animals treated with chitosan only show a slight erythrocytes increase. Variations in erythrocyte and leukocyte count and some biochemical parameters were observed in animals treated with chitosan acid salts. One g/kg orally was found to be the subacute NOAEL for chitosan due to the hematological findings observed were not considered adverse. Chitosans obtained from Panurilus argus lobster shell have low toxicity and may be safe in rats because it did not cause any lethality or changes in the general behavior in both the single and repeated dose toxicity studies.
- Subjects :
- Blood Glucose
Male
Erythrocytes
Biocompatibility
Administration, Oral
Cell Count
macromolecular substances
Biochemistry
Chitosan
chemistry.chemical_compound
Structural Biology
Decapoda
Leukocytes
Toxicity Tests, Acute
Animals
Rats, Wistar
Molecular Biology
Chromatography
Dose-Response Relationship, Drug
Low toxicity
Body Weight
technology, industry, and agriculture
Organ Size
General Medicine
Biodegradation
equipment and supplies
Repeat dose
Acute toxicity
carbohydrates (lipids)
chemistry
Toxicity
Female
Salts
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....26e618114ddb4a122dcfa2488ed7cf27
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2014.10.030