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Viscous control of cellular respiration by membrane lipid composition

Authors :
Christopher J. Petzold
Tristan de Rond
Leanne Jade G. Chan
Yan Chen
Itay Budin
Jay D. Keasling
Source :
Science. 362:1186-1189
Publication Year :
2018
Publisher :
American Association for the Advancement of Science (AAAS), 2018.

Abstract

How membrane viscosity affects respiration In bacteria, energy production by the electron transport chain occurs at cell membranes and can be influenced by the lipid composition of the membrane. Budin et al. used genetic engineering to influence the concentration of unsaturated branched-chain fatty acids and thus control membrane viscosity (see the Perspective by Schon). Experimental measurements and mathematical modeling indicated that rates of respiratory metabolism and rates of cell growth were dependent on membrane viscosity and its effects on diffusion. Experiments on yeast mitochondria also showed similar effects. Maintaining efficient respiration may thus place evolutionary constraints on cellular lipid composition. Science , this issue p. 1186 ; see also p. 1114

Details

ISSN :
10959203 and 00368075
Volume :
362
Database :
OpenAIRE
Journal :
Science
Accession number :
edsair.doi.dedup.....26e46fe8edc6bc690a61aace6aa30613