Back to Search
Start Over
Viscous control of cellular respiration by membrane lipid composition
- Source :
- Science. 362:1186-1189
- Publication Year :
- 2018
- Publisher :
- American Association for the Advancement of Science (AAAS), 2018.
-
Abstract
- How membrane viscosity affects respiration In bacteria, energy production by the electron transport chain occurs at cell membranes and can be influenced by the lipid composition of the membrane. Budin et al. used genetic engineering to influence the concentration of unsaturated branched-chain fatty acids and thus control membrane viscosity (see the Perspective by Schon). Experimental measurements and mathematical modeling indicated that rates of respiratory metabolism and rates of cell growth were dependent on membrane viscosity and its effects on diffusion. Experiments on yeast mitochondria also showed similar effects. Maintaining efficient respiration may thus place evolutionary constraints on cellular lipid composition. Science , this issue p. 1186 ; see also p. 1114
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Multidisciplinary
Viscosity
Cellular respiration
Cell Membrane
030106 microbiology
Biological membrane
medicine.disease_cause
Electron transport chain
Mitochondria
Oxygen
Membrane Lipids
03 medical and health sciences
030104 developmental biology
Enzyme
Membrane
chemistry
Escherichia coli
Fatty Acids, Unsaturated
medicine
Biophysics
Inner membrane
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 362
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....26e46fe8edc6bc690a61aace6aa30613