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V1a-vasopressin specific receptors on human platelets : Potentiation by ADP and epinephrine and evidence for homologous down-regulation
- Source :
- Thrombosis Research. 45:323-331
- Publication Year :
- 1987
- Publisher :
- Elsevier BV, 1987.
-
Abstract
- Using very specific vasopressin (VP) analogues, the human platelet VP receptor was characterized as a V1a rather than a V1b receptor, on the basis of the effect of the analogues on shape-change and aggregation. The platelet VP binding sites appeared to be subject to homologous down-regulation by plasma VP, in view of the inverse correlation found between the maximal capacity of binding of tritiated VP to platelets and the immunoreactive VP concentration in poor platelet plasma from the same individual. Aggregating effect of VP on human platelets was potentiated by both ADP and epinephrine. In addition, VP was able to release serotonin from human platelets, but only at high concentration.
- Subjects :
- Adult
Blood Platelets
Receptors, Vasopressin
Serotonin
Vasopressin
medicine.medical_specialty
Epinephrine
Platelet Aggregation
Vasopressins
Peptide hormone
Substrate Specificity
Downregulation and upregulation
Internal medicine
medicine
Humans
Platelet
Binding site
Receptor
Binding Sites
Receptors, Angiotensin
Chemistry
Hematology
Middle Aged
Adenosine Diphosphate
Arginine Vasopressin
Endocrinology
medicine.drug
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Thrombosis Research
- Accession number :
- edsair.doi.dedup.....26d9c81eb1e5d2ddb522ea1a490156e5
- Full Text :
- https://doi.org/10.1016/0049-3848(87)90221-0