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Malignant transformation rate and p53, and p16 expression in teratomatous skin of ovarian mature cystic teratoma
- Source :
- Asian Pacific journal of cancer prevention : APJCP. 16(3)
- Publication Year :
- 2015
-
Abstract
- Objective: To investigate the incidence of malignant transformation and P53 and P16 expression in teratomatous skin of ovarian mature cystic teratoma. Materials and Methods: Data on ovarian teratoma specimens in nearly 10 years were reviewed. P53 and P16 expression were detected by immunohistochemistry in 25 cases of teratomatous skin of ovarian mature cystic teratoma, 20 cases of squamous cell carcinoma and 2 cases of squamous cell carcinoma originated from teratomatous skin. Results: Of 1913 cases of ovarian mature cystic teratoma in nearly 10 years, only two cases of squamous cell carcinoma were found in teratomatous skin, with malignant transformation rate of 0.1045%. P53 expression was detected in 2 cases squamous cell carcinoma originated from teratomatous skin and P16 overexpression in one. There were no expressions of P53 and P16 in 25 cases of teratomatous skin of ovarian mature cystic teratoma. Of 20 cases of squamous cell carcinoma P53 overexpression (positive rate of 55%) was detected in 11 cases, P16 overexpression (positive rate of 35%) in 7 cases. The positive rates of P53 and P16 expression in squamous cell carcinomas were significantly higher than that in the teratomatous skins (p< 0.001, p= 0.002). Conclusions: There was low risk of malignant transformation in teratomatous skin of ovarian mature cystic teratoma which can be explained by lower P53 and P16 expressionin teratomas than that in squamous cell carcinoma.
- Subjects :
- P53 overexpression
Adult
endocrine system
Cancer Research
Pathology
medicine.medical_specialty
Skin Neoplasms
endocrine system diseases
Adolescent
Epidemiology
Cell
Malignant transformation
Immunoenzyme Techniques
Young Adult
medicine
Biomarkers, Tumor
Humans
Basal cell
Ovarian Teratoma
P53 expression
Cyclin-Dependent Kinase Inhibitor p16
Neoplasm Staging
Ovarian Neoplasms
Ovarian mature cystic teratoma
business.industry
Public Health, Environmental and Occupational Health
Teratoma
Middle Aged
Prognosis
female genital diseases and pregnancy complications
Ovarian Cysts
medicine.anatomical_structure
Cell Transformation, Neoplastic
Oncology
Carcinoma, Squamous Cell
Immunohistochemistry
Female
Tumor Suppressor Protein p53
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 2476762X
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Accession number :
- edsair.doi.dedup.....26cbd857516b4265b42d0dd7bb7edea7