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Nuclear ErbB-2: a Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?
- Source :
- Hormonescancer. 10(2-3)
- Publication Year :
- 2018
-
Abstract
- Membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbB family of receptor tyrosine kinases, occurs in 15– 20% of breast cancers (BC) and constitutes a therapeutic target in this BC subtype (ErbB-2-positive). Although MErbB-2- targeted therapies have significantly improved patients’ clinical outcome, resistance to available drugs is still a major issue in the clinic. Lack of accurate biomarkers for predicting responses to anti-ErbB-2 drugs at the time of diagnosis is also an important unresolved issue. Hence, a better understanding of the ErbB-2 signaling pathway constitutes a critical task in the battle against BC. In its canonical mechanism of action, MErbB-2 activates downstream signaling pathways, which transduce its proliferative effects in BC. The dogma of ErbB-2 mechanism of action has been challenged by the demonstration that MErbB-2 migrates to the nucleus, where it acts as a transcriptional regulator. Accumulating findings demonstrate that nuclear ErbB-2 (NErbB-2) is involved in BC growth and metastasis. Emerging evidence also reveal a role of NErbB-2 in the response to available anti-MErbB-2 agents. Here, we will review NErbB-2 function in BC and will particularly discuss the role of NErbB-2 as a novel target for therapy in ErbB-2-positive BC. Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Chervo, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Madera, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Charreau, Eduardo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
- Subjects :
- 0301 basic medicine
Cancer Research
Receptor, ErbB-2
Endocrinology, Diabetes and Metabolism
Apoptosis
NUCLEAR ERBB-2
Receptor tyrosine kinase
Metastasis
Phosphatidylinositol 3-Kinases
0302 clinical medicine
Endocrinology
Transcriptional regulation
Molecular Targeted Therapy
ERBB-2 SIGNALING PATHWAY
Neoplasm Metastasis
biology
Bioquímica y Biología Molecular
Treatment Outcome
Oncology
TRANSCRIPTIONAL COACTIVATOR
030220 oncology & carcinogenesis
Female
medicine.symptom
Signal transduction
CIENCIAS NATURALES Y EXACTAS
Signal Transduction
Cell Survival
Systems biology
Antineoplastic Agents
Breast Neoplasms
Ciencias Biológicas
03 medical and health sciences
Breast cancer
ErbB
BREAST CANCER
medicine
Biomarkers, Tumor
Humans
Cell Nucleus
Endocrine and Autonomic Systems
business.industry
medicine.disease
030104 developmental biology
Mechanism of action
Drug Resistance, Neoplasm
biology.protein
Cancer research
business
Proto-Oncogene Proteins c-akt
Biomarkers
Subjects
Details
- ISSN :
- 18688500
- Volume :
- 10
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Hormonescancer
- Accession number :
- edsair.doi.dedup.....26bf6a0b9393ab44f090a2292eb7525c