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Antidiabetic activity of hydro-alcoholic stem bark extract of Callicarpa arborea Roxb. with antioxidant potential in diabetic rats
- Source :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 95
- Publication Year :
- 2017
-
Abstract
- Despite the availability of synthetic antidiabetic drugs, diabetes mellitus is still affecting millions of people with increasing rate of disease incidence and mortality throughout the world. Ethnomedicinal survey documents the traditional usefulness of Callicarpa arborea Roxb. stem bark in the management of diabetes mellitus.In our study, hydro-alcoholic extract (HAE) of Callicarpa arborea stem bark was prepared according to WHO guidelines for herbal drugs, and screened for antidiabetic activity in streptozotocin (STZ)-induced diabetic rats. Acute oral toxicity and in vitro antioxidant activity studies along with phytochemical analyses of HAE were also carried out.Acute oral toxicity study indicated that HAE was safe up to a dose of 2000mg/kg body weight of rats. Results of antidiabetic activity study revealed that HAE of C. arborea stem bark possesses significant (p0.05) hypoglycemic activity compared to normal control group in experimental rats. Histological observations of treated pancreas and liver tissues confirmed the antidiabetic efficacy of HAE. In antioxidant activity, HAE exhibited significant radical scavenging activity.From results, it can be concluded that HAE of C. arborea stem bark may have possible role as herbal antioxidants in the prevention and/or treatment of oxidative stress-induced diabetes mellitus. The antioxidant property of plant phenolic and flavonoid contents present in HAE might be responsible for the antidiabetic efficacy of C. arborea stem bark.
- Subjects :
- 0301 basic medicine
Callicarpa arborea
Antioxidant
medicine.medical_treatment
Flavonoid
Antioxidant potential
Callicarpa
complex mixtures
Antioxidants
Diabetes Mellitus, Experimental
03 medical and health sciences
0302 clinical medicine
Superoxides
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Pharmacology
chemistry.chemical_classification
Stem bark
Traditional medicine
Plant Stems
business.industry
Plant Extracts
General Medicine
Streptozotocin
medicine.disease
Rats
030104 developmental biology
Phytochemical
chemistry
030220 oncology & carcinogenesis
Plant Bark
business
medicine.drug
Subjects
Details
- ISSN :
- 19506007
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie
- Accession number :
- edsair.doi.dedup.....26aa425cd2ed619d0ec864c138150839