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Genetic variants of AICDA/CASP14 associated with childhood brain tumor
- Source :
- Genetics and Molecular Research. 12:2024-2031
- Publication Year :
- 2013
- Publisher :
- Genetics and Molecular Research, 2013.
-
Abstract
- We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium-based algorithm. Five tag SNPs in 2 genes (AICDA and CASP14) remained significant after adjusted multiple tests. The most significant association with childhood brain tumor risk was for IVS1-401G>C in the AICDA gene [odds ratio (OR) = 2.8; 95% confidence interval (95%CI) = 1.25-6.46]; the polymorphism *9276A>C of CASP14 was associated with decreased brain tumor risk (OR = 0.4; 95%CI = 0.19-0.95). We concluded that genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Brain tumor
Apoptosis
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Risk Factors
Polymorphism (computer science)
Cytidine Deaminase
Internal medicine
Republic of Korea
Genetics
medicine
Activation-induced (cytidine) deaminase
Humans
Genetic Predisposition to Disease
Child
Molecular Biology
Gene
Genetic Association Studies
biology
Brain Neoplasms
business.industry
Cell Cycle
General Medicine
Odds ratio
Cell cycle
medicine.disease
Confidence interval
Caspases
Child, Preschool
biology.protein
Female
business
Subjects
Details
- ISSN :
- 16765680
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Genetics and Molecular Research
- Accession number :
- edsair.doi.dedup.....269bf4caddd30e63ee240b78c75fc8d0