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Upfront autologous hematopoietic stem cell transplantation in patients with high-risk stage III to IV Hodgkin lymphoma: a multicenter retrospective cohort study
- Source :
- Hematology. 24:225-231
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Nearly 30% of patients with advanced-stage Hodgkin lymphoma (HL) are not cured. We should better control tumors with initial treatment for patients with advanced stage HL whose interim positron emission tomography/computed tomography (PET/CT) was positive. The objective of our study was to confirm the superiority of autologous hematopoietic stem cell transplantation (ASCT) therapy in these patients.Eighty-nine HL patients with stage III-IV, international prognostic score (IPS) ≥3 and Deauville more than 3° at the interim PET/CT were analyzed. Forty five patients received ASCT. The other 44 patients received two cycles DHAP chemotherapy.The 3-year overall survival (OS) of patients who received ASCT was 91.1%, and for the patients who received chemotherapy, it was 72.7% (P = 0.025). The 3-year progression free survival (PFS) of patients in the ASCT group was 88.9%, but for patients in the chemotherapy group, it was only 70.5%(P = 0.017). No patient died of toxicity from ASCT. Additionally, there was no difference in the rates of secondary malignancies between the ASCT and chemotherapy groups. Extranodal and bone marrow involvement were poor prognostic factors, while ASCT was a good prognostic factor.The use of ASCT as a first-line consolidation treatment could improve outcome of patients with advanced-stage high risk HL whose interim PET/CT was positive.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Transplantation Conditioning
medicine.medical_treatment
Hematopoietic stem cell transplantation
Transplantation, Autologous
03 medical and health sciences
0302 clinical medicine
Risk Factors
immune system diseases
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Initial treatment
In patient
Stage (cooking)
Neoplasm Staging
Retrospective Studies
business.industry
Advanced stage
Hematopoietic Stem Cell Transplantation
Retrospective cohort study
Hematology
Hodgkin Disease
030220 oncology & carcinogenesis
Hodgkin lymphoma
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 16078454
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Hematology
- Accession number :
- edsair.doi.dedup.....269006c59612c5a2199500dd2576112d