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Delayed gastric emptying determined using the 13C-octanoic acid breath test in patients with systemic sclerosis
- Source :
- Arthritis & Rheumatism. 64:2346-2355
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Objective To determine the prevalence of delayed gastric emptying using the 13C–octanoic acid breath test in unselected patients with systemic sclerosis (SSc), to evaluate whether findings of the 13C–octanoic acid breath test are associated with clinical digestive manifestations, gastric mucosal abnormalities detected by gastroscopy, motor activity dysfunction detected by antroduodenal manometry, and esophageal motor impairment and extradigestive manifestations of SSc, and to develop a risk prediction score of gastric emptying in SSc. Methods Consecutive patients with SSc (n = 57) underwent the 13C–octanoic acid breath test. All of the patients with SSc completed a questionnaire on digestive symptoms, and a global symptom score (GSS) was calculated. Results The prevalence of delayed gastric emptying was 47.4% in patients with SSc. A marked correlation was observed between a GSS of digestive symptoms ≥5 and the presence of delayed gastric emptying (P < 0.00001). The sensitivity of a GSS ≥5 for predicting delayed gastric emptying was as high as 0.93, while the specificity was 0.73. Moreover, a GSS ≥5, mucosal gastric abnormalities, severe esophageal motor impairment, and interstitial lung disease were factors that were independently associated with the presence of delayed gastric emptying, and these variables were used to create a risk prediction score. The area under the receiver operating characteristic curve for the risk prediction score was 0.90; the sensitivity of this score for the prediction of delayed gastric emptying was 0.93, while the specificity was 0.77. Conclusion The results indicate that delayed gastric emptying occurs often in patients with SSc. Interestingly, using risk models with routine clinical characteristics, a simple risk prediction score can be calculated, allowing prediction of the occurrence of delayed gastric emptying in patients with SSc.
- Subjects :
- Adult
Male
medicine.medical_specialty
Gastroparesis
Immunology
Sensitivity and Specificity
Gastroenterology
Rheumatology
Surveys and Questionnaires
Internal medicine
medicine
Humans
Immunology and Allergy
Pharmacology (medical)
In patient
Motor activity
Aged
Aged, 80 and over
Breath test
Carbon Isotopes
Prediction score
Scleroderma, Systemic
Gastric emptying
medicine.diagnostic_test
Receiver operating characteristic
business.industry
digestive, oral, and skin physiology
Interstitial lung disease
Middle Aged
medicine.disease
Breath Tests
Gastric Emptying
Female
business
Symptom score
Subjects
Details
- ISSN :
- 00043591
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Arthritis & Rheumatism
- Accession number :
- edsair.doi.dedup.....268e27abfb1895809715c40984455c3b