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Biodegradable Screws Containing Bone Morphogenetic Protein-2 in an Osteoporotic Rat Model
- Source :
- Journal of Korean Neurosurgical Society
- Publication Year :
- 2018
- Publisher :
- Korean Neurosurgical Society, 2018.
-
Abstract
- Objective The aim of this study was to evaluate the effect for biodegradable screws containing bone morphogenetic protein-2 (BMP-2) in an osteoporotic rat model. Methods Twenty-four female Wistar rat (250–300 g, 12 weeks of age) were randomized into four groups. Three groups underwent bilateral ovariectomy (OVX). Biodegradable screws with or without BMP-2 were inserted in the proximal tibia in two implantation groups. The extracted proximal metaphysis of the tibiae were scanned by exo-vivo micro-computed tomography. Evaluated parameters included bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number, trabecular thickness, and trabecular separation (Tb.Sp). The tibia samples were pathologically evaluated by staining with by Hematoxylin and Eosin, and trichrome. Results Trabecular formation near screw insertion site was evident only in rats receiving BMP-2 screws. BMD and BV/TV significantly differed between controls and the OVX and OVX with screw groups. However, there were no significant differences between control and OVX with screw BMP groups. Tb.Sp significantly differed between control and OVX and OVX with screw groups (p
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Osteoporosis
Rat model
H&E stain
Dentistry
Bone morphogenetic protein 2
Proximal metaphysis
03 medical and health sciences
0302 clinical medicine
Medicine
Tibia
Bone mineral
business.industry
General Neuroscience
Screw, Animal
030206 dentistry
equipment and supplies
musculoskeletal system
medicine.disease
surgical procedures, operative
030104 developmental biology
Others
Models, Animal
Laboratory Investigation
Surgery
Neurology (clinical)
Implant
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15987876 and 20053711
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Neurosurgical Society
- Accession number :
- edsair.doi.dedup.....267dae1518e575e506e683c447c0d226