Back to Search
Start Over
Polyamine deficient diet to relieve pain hypersensitivity
- Source :
- Pain. 137:125-137
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- There is a compelling body of evidence that N-methyl-d-aspartate receptors (NMDA-R) play a critical role in the development and maintenance of pain hypersensitivity. However, long-term treatments with NMDA-R antagonists are limited by unacceptable side effects. Since polyamines modulate the functioning of NMDA-R and mainly originate from normal dietary intake and bacterial metabolism in the gut, we developed a nutritional therapy based on dietary polyamine deficiency. Here, we reported that a polyamine deficient diet (PD diet) for 7 days prevented the enhancement of tyrosine phosphorylation of the spinal NR2B subunit-containing NMDA-R associated with inflammation in rats. Based on these data, we studied the ability of PD diet to prevent long-lasting pain hypersensitivity associated with tissue injury on one hind paw by evaluating long-lasting changes in both mechanical nociceptive threshold and weight bearing. A PD diet strongly reduced long-lasting hyperalgesia induced by inflammation or incision, especially in fentanyl-treated rats. Moreover a PD diet also prevented the exaggerated hyperalgesia induced by a second inflammation performed 7 days after the first one. A PD diet also opposed paradoxical hyperalgesia induced by non-nociceptive environmental stress in rats with pain and opioid experiences. A PD diet reversed pain hypersensitivity associated with monoarthritis or neuropathy and restored the analgesic effect of morphine. Since PD diet was devoid of any noticeable side effects, this nutritional therapy could be part of an effective and safe strategy for pre-emptive analgesia and for reducing the transition from acute to chronic pain and its outcomes in various pain syndromes.
- Subjects :
- Male
medicine.medical_specialty
Diet therapy
Rats, Sprague-Dawley
Internal medicine
Polyamines
Putrescine
medicine
Monoarthritis
Animals
Medical nutrition therapy
Pain Measurement
business.industry
Chronic pain
medicine.disease
Rats
Anesthesiology and Pain Medicine
Endocrinology
Nociception
Neurology
Opioid
Hyperalgesia
Anesthesia
Morphine
Neurology (clinical)
medicine.symptom
business
Diet Therapy
medicine.drug
Subjects
Details
- ISSN :
- 03043959
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Pain
- Accession number :
- edsair.doi.dedup.....266fd85e925732a91f4675a3f70e70c2