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Regulation of endocytosis by the small GTP-ase Rab5
- Source :
- Cytotechnology. 11(Suppl 1)
- Publication Year :
- 2012
-
Abstract
- Rab5 is a small GTPase associated with the plasma membrane and the early endosomes. Expression of wild type rab5 and a mutant protein defective in GTP-binding in BHK cells led to alterations in the rate of endocytosis and in the morphology of endocytic organelles. The results obtained suggest that rab5 is a rate limiting GTPase that regulate the kinetics of both lateral fusion of early endosomes and fusion of plasma membrane-derived endocytic vesicles with early endosomes.
- Subjects :
- Endosome
Clinical Biochemistry
Endocytic cycle
Biomedical Engineering
Bioengineering
GTPase
Biology
Endocytosis
environment and public health
Membrane Fusion
Bulk endocytosis
Cell Line
GTP Phosphohydrolases
GTP-Binding Proteins
Cricetinae
Animals
Small GTPase
Late endosome
rab5 GTP-Binding Proteins
fungi
Cell Biology
Cell biology
enzymes and coenzymes (carbohydrates)
Endocytic vesicle
Mutation
biological phenomena, cell phenomena, and immunity
Biotechnology
Subjects
Details
- ISSN :
- 09209069
- Volume :
- 11
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- Cytotechnology
- Accession number :
- edsair.doi.dedup.....2662662f050d43bd7e1d8da15eebb9e5