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Prognostic Value and Clinicopathological Features of MicroRNA-206 in Various Cancers: A Meta-Analysis
- Source :
- BioMed Research International, Vol 2020 (2020), BioMed Research International
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- It has been reported that microRNA-206(miR-206) plays an important role in cancers and could be used as a prognostic biomarker. However, the results are controversial. Therefore, we summarize all available evidence and present a meta-analysis to estimate the prognostic value of miR-206 in various cancers. The relevant studies were collected by searching PubMed, EMBASE, and Web of Science databases until August 21, 2020. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the association between miR-206 and survival results and clinicopathologic features. Sources of heterogeneity were investigated by subgroup analysis and sensitivity analysis. Publication bias was evaluated using Egger’s test. Twenty articles involving 2095 patients were included in the meta-analysis. The pooled HR showed that low miR-206 expression was significantly associated with unfavourable overall survival (OS) ( HR = 2.03 , 95 CI%: 1.53-2.70, P < 0.01 ). In addition, we found that low miR-206 expression predicted significantly negative association with tumor stage (III-IV VS. I-II) ( OR = 4.20 , 95% CI: 2.17-8.13, P < 0.01 ), lymph node status (yes VS. no) ( OR = 3.58 , 95%: 1.51-8.44, P = 0.004 ), distant metastasis (yes VS. no) ( OR = 3.19 , 95%: 1.07-9.50, P = 0.038 ), and invasion depth ( T 3 + T 4 vs. T 2 + T 1 ) ( OR = 2.43 , 95%: 1.70-3.49, P < 0.01 ). miR-206 can be used as an effective prognostic indicator in various cancers. Further investigations are warranted to validate the present results.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Subgroup analysis
Review Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Text mining
Neoplasms
Internal medicine
Databases, Genetic
Biomarkers, Tumor
Odds Ratio
medicine
Humans
Child
Lymph node
Neoplasm Staging
Proportional Hazards Models
General Immunology and Microbiology
business.industry
Hazard ratio
General Medicine
Odds ratio
Publication bias
Prognosis
Confidence interval
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Meta-analysis
Medicine
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....26612248910a40cf864233f4c34da68e