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Clinical and Neurophysiological Correlates of Emotion and Food Craving Regulation in Patients with Anorexia Nervosa
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 960, p 960 (2020), Journal of Clinical Medicine, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Clinical Medicine; Volume 9; Issue 4; Pages: 960
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Background: Difficulties in emotion regulation and craving regulation have been linked to eating symptomatology in patients with anorexia nervosa (AN), contributing to the maintenance of their eating disorder. Methods: To investigate clinical and electrophysiological correlates of these processes, 20 patients with AN and 20 healthy controls (HC) completed a computerized task during EEG recording, where they were instructed to down-regulate negative emotions or food craving. Participants also completed self-report measures of emotional regulation and food addiction. The P300 and Late Positive Potential (LPP) ERPs were analysed. Results: LPP amplitudes were significantly smaller during down-regulation of food craving among both groups. Independent of task condition, individuals with AN showed smaller P300 amplitudes compared to HC. Among HC, the self-reported use of re-appraisal strategies positively correlated with LPP amplitudes during emotional regulation task, while suppressive strategies negatively correlated with LPP amplitudes. The AN group, in comparison to the HC group, exhibited greater food addiction, greater use of maladaptive strategies, and emotional dysregulation. Conclusions: Despite the enhanced self-reported psychopathology among AN, both groups indicated neurophysiological evidence of food craving regulation as evidenced by blunted LPP amplitudes in the relevant task condition. Further research is required to delineate the mechanisms associated with reduced overall P300 amplitudes among individuals with AN.<br />This manuscript and research were supported by grants from the Instituto de Salud Carlos III (ISCIII) [FIS PI14/00290, PI17/01167 and cofounded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe]. CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) is an initiative of ISCIII. M.L-M and C.V-A are supported by a predoctoral grants of the Ministerio de Educacion, Cultura y Deporte (FPU15/02911 and FPU16/01453). Study resulting from the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya by the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut". We thank CERCA Programme/Generalitat de Catalunya for Institutional support.
- Subjects :
- 050103 clinical psychology
emotion regulation
Food craving
Food addiction
Event-related potentials (ERPs)
Neurophysiology
lcsh:Medicine
Craving
eating disorders
Article
anorexia nervosa
03 medical and health sciences
0302 clinical medicine
Event-related potential
Neurofisiologia
food craving
food addiction
event related potentials
EEG
neurophysiology
psychopathology
mental disorders
Medicine
0501 psychology and cognitive sciences
Trastorns de la gana
Psychopathology
business.industry
05 social sciences
digestive, oral, and skin physiology
lcsh:R
Anorèxia nerviosa
General Medicine
Anorexia nervosa
Event related potentials
Emotional dysregulation
medicine.disease
Eating disorders
Anorexia nervosa (differential diagnoses)
Emotion Regulation
Appetite disorders
medicine.symptom
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 960
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....265d3ac11a0b66ee760d8c9fd939f1ec