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Long non-coding RNAs regulation in adipogenesis and lipid metabolism: Emerging insights in obesity
- Source :
- Cellular Signalling. 51:47-58
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of >200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity.
- Subjects :
- 0301 basic medicine
Adipose Tissue, White
Future application
Adipose tissue
Computational biology
Biology
Mice
03 medical and health sciences
Adipose Tissue, Brown
Brown adipocyte differentiation
medicine
Animals
Homeostasis
Humans
Obesity
Cholesterol homeostasis
Adipogenesis
Thermogenesis
Lipid metabolism
Cell Biology
Lipid Metabolism
medicine.disease
030104 developmental biology
RNA, Long Noncoding
Subjects
Details
- ISSN :
- 08986568
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Cellular Signalling
- Accession number :
- edsair.doi.dedup.....265c49dc521a15727a3fe1964bf9243f