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Integrated analysis of gait parameters and gene expression profiles in a murine model of subarachnoid hemorrhage
- Source :
- Genes, Brain and Behavior. 20
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Gait analysis has been widely used to examine the behavioral presentation of numerous neurological disorders. Thorough murine model evaluation of the subarachnoid hemorrhage (SAH)-associated gait deficits is missing. This study measures gait deficits using a clinically relevant murine model of SAH to examine associations between gait variability and SAH-associated gene expressions. A total of 159 dynamic and static gait parameters from the endovascular perforation murine model for simulating clinical human SAH were determined using the CatWalk system. Eighty gait parameters and the mRNA expression levels of 35 of the 88 SAH-associated genes were differentially regulated in the diseased models. Totals of 42 and 38 gait parameters correlated with the 35 SAH-associated genes positively and negatively with Pearson's correlation coefficients of >0.7 and
- Subjects :
- Male
0301 basic medicine
Subarachnoid hemorrhage
Perforation (oil well)
Bioinformatics
Mice
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Gait (human)
Genetics
medicine
Animals
Muscle Strength
cardiovascular diseases
Pathological
Stroke
business.industry
Brain
Subarachnoid Hemorrhage
medicine.disease
nervous system diseases
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Neurology
Gait analysis
Biomarker (medicine)
Gait Analysis
Transcriptome
business
human activities
030217 neurology & neurosurgery
Motor cortex
Subjects
Details
- ISSN :
- 1601183X and 16011848
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Genes, Brain and Behavior
- Accession number :
- edsair.doi.dedup.....26394a26635ada2e1a491d08083ea4c2