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Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals
- Source :
- Journal of Immunology, Journal of Immunology, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- HIV-1 infection is associated with B cell dysregulation and dysfunction. In HIV-1–infected patients, we previously reported preservation of intestinal lymphoid structures and dendritic cell maturation pathways after early combination antiretroviral therapy (e-ART), started during the acute phase of the infection, compared with late combination antiretroviral therapy started during the chronic phase. In this study, we investigated whether the timing of combination antiretroviral therapy initiation was associated with the development of the HIV-1–specific humoral response in the gut. The results showed that e-ART was associated with higher frequencies of functional resting memory B cells in the gut. These frequencies correlated strongly with those of follicular Th cells in the gut. Importantly, frequencies of HIV-1 Env gp140–reactive B cells were higher in patients given e-ART, in whom gp140-reactive IgG production by mucosal B cells increased after stimulation. Moreover, IL-21 release by PBMCs stimulated with HIV-1 peptide pools was greater with e-ART than with late combination antiretroviral therapy. Thus, early treatment initiation helps to maintain HIV-1–reactive memory B cells in the gut as well as follicular Th cells, whose role is crucial in the development of potent affinity-matured and broadly neutralizing Abs.
- Subjects :
- Male
0301 basic medicine
[SDV]Life Sciences [q-bio]
Human immunodeficiency virus (HIV)
HIV Infections
Stimulation
MESH: Immunologic Memory / drug effects
medicine.disease_cause
MESH: Interleukins / metabolism
0302 clinical medicine
Follicular phase
Immunology and Allergy
Medicine
MESH: env Gene Products, Human Immunodeficiency Virus / metabolism
Intestinal Mucosa
MESH: Aged
B-Lymphocytes
MESH: Middle Aged
env Gene Products, Human Immunodeficiency Virus
T-Lymphocytes, Helper-Inducer
Middle Aged
3. Good health
Intestines
medicine.anatomical_structure
Anti-Retroviral Agents
MESH: HIV Infections / drug therapy
MESH: B-Lymphocytes / virology
MESH: T-Lymphocytes, Helper-Inducer / drug effects
Female
Adult
Immunology
Peripheral blood mononuclear cell
MESH: T-Lymphocytes, Helper-Inducer / virology
03 medical and health sciences
MESH: Intestines / drug effects
Humans
In patient
B cell
Aged
MESH: Anti-Retroviral Agents / therapeutic use
MESH: Humans
business.industry
Interleukins
MESH: Adult
Dendritic cell
MESH: B-Lymphocytes / drug effects
Antiretroviral therapy
MESH: HIV-1 / drug effects
MESH: Male
030104 developmental biology
HIV-1
business
Immunologic Memory
MESH: Intestinal Mucosa / drug effects
MESH: Intestinal Mucosa / virology
MESH: Female
030215 immunology
MESH: Intestines / virology
Subjects
Details
- Language :
- English
- ISSN :
- 00221767 and 15506606
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology, Journal of Immunology, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
- Accession number :
- edsair.doi.dedup.....2622102e5901a8a1bf6c99603c6ba9c4