Determination, characterization and modeling of aqueous biphasic systems composed of propylammonium-based ionic liquids and phosphate salts

Made available in DSpace on 2020-12-12T01:24:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Ionic liquids (ILs)-based aqueous biphasic systems (ABS) are efficient platforms for the extraction and purification of biomolecules. To find more biocompatible ABS, propylammonium-based ILs, phosphate salts and water were mixed at three temperatures, evaluating the influence of IL and temperature on the liquid-liquid equilibria (LLE). The biphasic region increases with the increase of IL’ anionic/cationic chain and decreases with the increase of temperature. There is good agreement between the IL’ ability to form ABS and the hydrogen bonding interaction predicted by COSMO-RS. The subtle balance of hydrogen bonding between salt anion-water and IL anion-water governs the phase separation. Department of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP) CICECO-Aveiro Institute of Materials Department of Chemistry University of Aveiro Department of Chemical Engineering Federal University of Paraná (UFPR), Polytechnic Center Department of Marine Faculty of Fisheries and Marine Universitas Airlangga Jalan Mulyorejo Kampus C Univ Coimbra CIEPQPF Department of Chemical Engineering Rua Sílvio Lima, Pólo II – Pinhal de Marrocos Department of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP) FAPESP: 2014/16424-7 FAPESP: 2014/19793-3 FAPESP: 2015/50058-0 CNPq: 310182/2018