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Thrombospondin-4 in tissue remodeling
- Source :
- Matrix Biology. :300-313
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that consists of five highly homologous members. A number of novel functions have been recently assigned to TSP-4 in cardiovascular and nervous systems, inflammation, cancer, and the motor unit, which have attracted attention to this extracellular matrix (ECM) protein. These newly discovered functions set TSP-4 apart from other thrombospondins. For example, TSP-4 promotes angiogenesis while other TSPs either prevent it or have no effect on new blood vessel growth; TSP-4 reduces fibrosis and collagen production while TSP-1 and TSP-2 promote fibrosis in several organs; unlike other TSPs, TSP-4 appears to have some structural functions in ECM. The current information about TSP-4 functions in different organs and physiological systems suggests that this evolutionary conserved protein is a major regulator of the extracellular matrix (ECM) organization and production and tissue remodeling during the embryonic development and response to injury. In this review article, we summarize the properties and functions of TSP-4 and discuss its role in tissue remodeling.
- Subjects :
- 0301 basic medicine
endocrine system
Protein family
Angiogenesis
Regulator
Biology
Article
Thrombospondin 1
Extracellular matrix
03 medical and health sciences
immune system diseases
Fibrosis
Thrombospondin 4
medicine
Humans
Thrombospondins
education
Molecular Biology
Extracellular Matrix Proteins
Thrombospondin
education.field_of_study
Neovascularization, Pathologic
Gene Expression Regulation, Developmental
virus diseases
medicine.disease
Extracellular Matrix
Cell biology
030104 developmental biology
Immunology
Blood Vessels
Subjects
Details
- ISSN :
- 0945053X
- Database :
- OpenAIRE
- Journal :
- Matrix Biology
- Accession number :
- edsair.doi.dedup.....25f3efd5f9a95dc42c41601c7e739de5