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Existence of conventional dendritic cells in Gallus gallus revealed by comparative gene expression profiling
- Source :
- Journal of Immunology, Journal of Immunology, 2014, 192 (10), pp.4510-4517. ⟨10.4049/jimmunol.1303405⟩, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 192 (10), pp.4510-4517. ⟨10.4049/jimmunol.1303405⟩, The Journal of Immunology
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- The online version of this article contains supplemental material; International audience; The existence of conventional dendritic cells (cDCs) has not yet been demonstrated outside mammals. In this article, we identified bona fide cDCs in chicken spleen. Comparative profiling of global and of immune response gene expression, morphology, and T cell activation properties show that cDCs and macrophages (MPs) exist as distinct mononuclear phagocytes in the chicken, resembling their human and mouse cell counterparts. With computational analysis, core gene expression signatures for cDCs, MPs, and T and B cells across the chicken, human, and mouse were established, which will facilitate the identification of these subsets in other vertebrates. Overall, this study, by extending the newly uncovered cDC and MP paradigm to the chicken, suggests that these two phagocyte lineages were already in place in the common ancestor of reptiles (including birds) and mammals in evolution. It opens avenues for the design of new vaccines and nutraceuticals that are mandatory for the sustained supply of poultry products in the expanding human population.
- Subjects :
- Phagocyte
T-Lymphocytes
T cell
[SDV]Life Sciences [q-bio]
Immunology
Cell
Population
Spleen
Biology
Cell Line
Mice
medicine
Animals
Humans
Immunology and Allergy
education
education.field_of_study
Immune response gene
Gene Expression Profiling
Macrophages
Dendritic Cells
Cell biology
[SDV] Life Sciences [q-bio]
Gene expression profiling
medicine.anatomical_structure
Gene Expression Regulation
Cell culture
Chickens
Subjects
Details
- Language :
- English
- ISSN :
- 00221767 and 15506606
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology, Journal of Immunology, 2014, 192 (10), pp.4510-4517. ⟨10.4049/jimmunol.1303405⟩, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 192 (10), pp.4510-4517. ⟨10.4049/jimmunol.1303405⟩, The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....25d968113ddcd7fcac8cc7590aed088c