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A patient with plasmablastic lymphoma achieving long-term complete remission after thalidomide-dexamethasone induction and double autologous stem cell transplantation: a case report
- Source :
- BMC Cancer, Vol 18, Iss 1, Pp 1-5 (2018)
- Publication Year :
- 2018
-
Abstract
- Background No standard of care is established for plasmablastic lymphoma (PBL) and prognosis remains extremely poor, given that patients relapse early after chemotherapy and display resistance to commonly applied cytostatic drugs. Case presentation We report a case of nodal, HIV-unrelated PBL in a patient who achieved and maintained a very long lasting complete remission after an intensive therapy consisting consisting of thalidomide plus dexamethasone followed by a consolidation with double autologous stem cell transplantation. Our approach was based on the full application of a standard multiple myeloma treatment and, to the best of our knowledge, it represents the only reported experience so far. This treatment was overall well tolerated. Conclusions Multiple myeloma-like treatment may represent a possible alternative to intensive lymphoma-directed therapies.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Hematopoietic stem cell transplantation
lcsh:RC254-282
Transplantation, Autologous
Dexamethasone
03 medical and health sciences
0302 clinical medicine
Autologous stem-cell transplantation
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Genetics
medicine
Humans
Multiple myeloma
Chemotherapy
Antineoplastic Combined Chemotherapy Protocol
business.industry
Hematopoietic Stem Cell Transplantation
Induction chemotherapy
Induction Chemotherapy
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Thalidomide
Transplantation, Autologou
Treatment Outcome
030220 oncology & carcinogenesis
Plasmablastic Lymphoma
Female
business
Plasmablastic lymphoma
Human
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 14712407
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC cancer
- Accession number :
- edsair.doi.dedup.....25cb536625b65d417e7ecce60229aec8