Back to Search
Start Over
iPCSK9 treatment of Familial Hypercholesterolemia in a patient diagnosed as Congenital Muscular Dystrophy with contraindication for statin use
- Source :
- Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis. 31(6)
- Publication Year :
- 2018
-
Abstract
- Statins are contraindicated in patients with myopathies. Until a few years ago, in those patients with familial hypercholesterolemia who also presented muscular dystrophies and did not reach adequate cholesterol plasmatic levels, the next therapeutic ladder was lipoapheresis. When iPCSK9 first appeared, lipoapheresis could be suspended in some of these patients, sustaining nevertheless proper levels of cholesterol. We present the case of a 27 year-old male, diagnosed with congenital muscular dystrophy in the early childhood. He was referred to the Unit of Lipidology presenting hypercholesterolemia which, after genetic test, was assessed as heterozygous familial hypercholesterolemia. Despite of treatment with diet and ezetimibe, cLDL blood levels abide high, being consequently included in lipoapheresis programme, therewith obtained levels of cLDL of 70 mg/dl. In providing iPCSK9, lipoapheresis was withdrawn and treatment with alirocumab 150 mg fortnightly introduced, unveiling a positive response, and sustaining cLDL levels around 75 mg/dl.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Hypercholesterolemia
Familial hypercholesterolemia
Antibodies, Monoclonal, Humanized
Muscular Dystrophies
chemistry.chemical_compound
Ezetimibe
Medicine
Humans
Muscular dystrophy
Contraindication
General Environmental Science
Alirocumab
business.industry
Cholesterol
PCSK9 Inhibitors
General Engineering
Cholesterol, LDL
medicine.disease
chemistry
Congenital muscular dystrophy
General Earth and Planetary Sciences
business
Lipidology
medicine.drug
Subjects
Details
- ISSN :
- 15781879
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
- Accession number :
- edsair.doi.dedup.....25b60128fdb458e10fdcd1b0b85edeec