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Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 27:138-146
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background and Aim Preliminary findings indicate that consumption of Salba-chia ( Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes. Methods A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA 1c : 6.5–8.0%; BMI: 25–40 kg/m 2 ). Both groups followed a 6-month calorie-restricted diet; one group received 30 g/1000 kcal/day of Salba-chia, the other 36 g/1000 kcal/day of an oat bran-based control. Primary endpoint was change in body weight over 6-months. Secondary endpoints included changes in waist circumference, body composition, glycemic control, C-reactive protein, and obesity-related satiety hormones. Results At 6-months, participants on Salba-chia had lost more weight than those on control (1.9 ± 0.5 kg and 0.3 ± 0.4 kg, respectively; P = 0.020), accompanied by a greater reduction in waist circumference (3.5 ± 0.7 cm and 1.1 ± 0.7 cm, respectively; P = 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on Salba-chia, compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control ( P = 0.045). Plasma adiponectin on the test intervention increased by 6.5 ± 0.7%, with no change observed on control ( P = 0.022). Conclusions The results of this study, support the beneficial role of Salba-chia seeds in promoting weight loss and improvements of obesity related risk factors, while maintaining good glycemic control. Supplementation of Salba-chia may be a useful dietary addition to conventional therapy in the management of obesity in diabetes. Registration clinicaltrials.gov identifier: NCT01403571 .
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Time Factors
Waist
Diet, Reducing
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
Type 2 diabetes
Overweight
Gastroenterology
Management of obesity
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Weight loss
Diabetes mellitus
Internal medicine
Weight Loss
Humans
Medicine
Obesity
Salvia
Adiposity
Caloric Restriction
Glycemic
Ontario
Plants, Medicinal
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Middle Aged
medicine.disease
Treatment Outcome
Endocrinology
Diabetes Mellitus, Type 2
Seeds
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Phytotherapy
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....25b561d9eb1399a2a7e9093dd642a506