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Hyperthermia induced by the dopamine D1 receptor agonist SK&F38393 in combination with the dopamine D2 receptor agonist talipexole in the rat
- Source :
- Pharmacology Biochemistry and Behavior. 43:993-997
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- The present experiments were performed to investigate the effects of dopamine D1 receptor agonists given alone or in combination with dopamine D2 receptor agonists on body temperature in rats. The selective dopamine D1 receptor agonist, 1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol (SK&F38393), produced hyperthermia. However, the dopamine D2 receptor agonist, B-HT 920 (talipexole), and the newly synthesized dopamine D2 receptor agonist, (S)-2-amino-4,5,6,7-tetrahydro-6-propylamino-benzothiazole (SND 919), did not change the temperature. Interestingly, the SK&F38393-induced hyperthermia was enhanced by talipexole and SND 919. The drastic hyperthermia induced by combined administration of dopamine D1 and D2 receptor agonists was blocked by either the dopamine D1 receptor antagonist, SCH23390, or the dopamine D2 receptor antagonist, spiperone. On the other hand, treatment with prazosin, yohimbine, propranolol, scopolamine, or methysergide failed to affect the marked hyperthermia. The present results suggest that a functional link between dopamine D1 and D2 receptors may be synergistic in the regulation of body temperature and that concurrent stimulation of both dopamine D1 and D2 receptors thereby produces marked hyperthermia in the rat.
- Subjects :
- Male
Agonist
medicine.medical_specialty
Fever
medicine.drug_class
Dopamine Agents
Clinical Biochemistry
Receptors, Cell Surface
Pharmacology
Toxicology
Biochemistry
Partial agonist
Dopamine agonist
Body Temperature
Behavioral Neuroscience
Pramipexole
Dopamine receptor D1
Dopamine
Dopamine receptor D2
Internal medicine
medicine
Animals
Benzothiazoles
Rats, Wistar
Biological Psychiatry
Receptors, Dopamine D2
Chemistry
Receptors, Dopamine D1
Azepines
Talipexole
Rats
Thiazoles
Endocrinology
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Endogenous agonist
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....25b3cc716d073ea890462bf5bc84fedd