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Large-scale and contact-free fabrication of microwell arrays based on electro-pressure of depositing ions

Authors :
Jiading Wu
Jinglong Zou
Tingting Zhu
Sheng Liu
Huai Zheng
Peng Fei
Cao Li
Source :
AIP Advances, Vol 9, Iss 4, Pp 045317-045317-8 (2019)
Publication Year :
2019
Publisher :
AIP Publishing, 2019.

Abstract

Microwell arrays are showing great potentials for various optoelectronic and biological applications. However, large-scale fabrication of microwell arrays remains a big challenge to modern micro- and nanotechnology. Here, we report a novel fabrication method that can produce massive aligned microwells in a cost-effective way. With using ionic wind, the hole arrays of pre-fabricated masks can be projected on polymer films and form microwell arrays in a contact-free way, and at high efficiency. Thousands of microwells can be rapidly fabricated in several minutes with their parameters, such as shape, size, and density, being widely tunable, through adjusting the mask’s design and its location in the ionic wind. The fabricated circle and square holes in microwells perfectly replicate the features from the mask, thus being successfully used to trap suspension cells and culture them sustainably till significant cell patterns are formed.

Details

ISSN :
21583226
Volume :
9
Database :
OpenAIRE
Journal :
AIP Advances
Accession number :
edsair.doi.dedup.....258d54c74202c1afc0645f78349e67e5
Full Text :
https://doi.org/10.1063/1.5092673