Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy

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Highlights • Supramolecular hydrogel was facilely developed by self-assembly of NO prodrug conjugated hydrogelator sequence. • The locoregionally sustained NO release from the hydrogel could be triggered by intracellular over-expressed GSH/GST. • NO could effectively reverse the P-gp mediated MDR effect and facilitate the intracellular accumulation of DOX. • This type of stimuli-sensitive NO delivery platform holds great potential for combating drug-resistance cancer.