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High-Resolution Microfluidic Single-Cell Transcriptional Profiling Reveals Clinically Relevant Subtypes among Human Stem Cell Populations Commonly Utilized in Cell-Based Therapies
- Source :
- Frontiers in Neurology, Frontiers in Neurology, Vol 7 (2016)
- Publication Year :
- 2016
- Publisher :
- Frontiers Media S.A., 2016.
-
Abstract
- Stem cell therapies can promote neural repair and regeneration, yet controversy regarding optimal cell source and mechanism of action has slowed clinical translation, potentially due to undefined cellular heterogeneity. Single-cell resolution is needed to identify clinically relevant subpopulations with the highest therapeutic relevance. We combine single-cell microfluidic analysis with advanced computational modeling to study for the first time two common sources for cell-based therapies, human NSCs and MSCs. This methodology has the potential to logically inform cell source decisions for any clinical application.
- Subjects :
- 0301 basic medicine
Cell
High resolution
single cell analysis
Computational biology
Bioinformatics
lcsh:RC346-429
Microfluidic Analysis
03 medical and health sciences
0302 clinical medicine
Single-cell analysis
Hypothesis and Theory
stem cell therapeutics
cellular heterogeneity
medicine
single-cell analysis
lcsh:Neurology. Diseases of the nervous system
business.industry
Mesenchymal stem cell
Stroke
030104 developmental biology
medicine.anatomical_structure
Neurology
Cellular heterogeneity
Neurology (clinical)
Neuroregeneration
Stem cell
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 16642295
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....25755b6424b94be0a60bf5dd1f332de5