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Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis
- Source :
- Clinical Rheumatology. 35:315-323
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- This study aims to derive a more precise estimation on carotid intima-media thickness (CIMT) level in patients with rheumatoid arthritis (RA) and related factors. Studies published from January 1, 1982 to December 31, 2014 in English, which comparing CIMT between RA group and control group were searched in PubMed, Embase, and Cochrane Library databases. Heterogeneity test was performed, and publication bias was evaluated. Stata software 12.0 was used to perform the meta-analysis. Two-thousand one hundred sixty-three articles were obtained after searching databases, and 47 studies were finally included in the meta-analysis. The result of the analysis in random effect model showed that RA group had significantly higher CIMT than control group, with the standardized mean difference (SMD) of 1.04 and 95% CI (0.81,1.27). To evaluate the stability of our results, sensitivity analyses were performed, and the results showed no significant change when any one study was excluded. Subgroup analyses showed that region, race, age, BMI, and disease duration were associated with CIMT in RA patients. In summary, CIMT in RA patients is thicker than healthy controls, and it is influenced by region, race, age, BMI, and disease duration.
- Subjects :
- medicine.medical_specialty
030204 cardiovascular system & hematology
Cochrane Library
Carotid Intima-Media Thickness
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
medicine
Humans
030203 arthritis & rheumatology
business.industry
General Medicine
Publication bias
Random effects model
medicine.disease
Observational Studies as Topic
Carotid Arteries
Intima-media thickness
Strictly standardized mean difference
Meta-analysis
Rheumatoid arthritis
cardiovascular system
Physical therapy
business
Subjects
Details
- ISSN :
- 14349949 and 07703198
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....2561ec734df2acb15f8f19c3e5fed597