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Glial responses to implanted electrodes in the brain
- Source :
- Nature biomedical engineering. 1(11)
- Publication Year :
- 2018
-
Abstract
- The use of implants that can electrically stimulate or record electrophysiological or neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in clinical studies and increasing market approvals, the mechanisms underlying the therapeutic effects of neuroprosthetic and neuromodulation devices, as well as their side effects and reasons for their failure, remain poorly understood. A major assumption has been that the signal-generating neurons are the only important target cells of neural-interface technologies. However, recent evidence indicates that the supporting glial cells remodel the structure and function of neuronal networks and are an effector of stimulation-based therapy. Here, we reframe the traditional view of glia as a passive barrier, and discuss their role as an active determinant of the outcomes of device implantation. We also discuss the implications that this has on the development of bioelectronic medical devices.
- Subjects :
- Implanted electrodes
Effector
business.industry
Nervous tissue
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
Stimulation
02 engineering and technology
021001 nanoscience & nanotechnology
Neuromodulation (medicine)
Article
Computer Science Applications
Structure and function
03 medical and health sciences
Electrophysiology
0302 clinical medicine
medicine.anatomical_structure
Neurochemical
Medicine
0210 nano-technology
business
Neuroscience
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 2157846X
- Volume :
- 1
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature biomedical engineering
- Accession number :
- edsair.doi.dedup.....2560d289628ee43b7512cf86e1b33567