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Soluble programmed death‐1 (sPD‐1) as predictor of early surgical outcomes of paediatric cystic echinococcosis
- Source :
- Parasite Immunology, Parasite Immunology, Wiley, 2021, 43 (3), pp.e12809. ⟨10.1111/pim.12809⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Aims Following treatment, cystic echinococcosis (CE) exhibits a relatively high relapse rate. Here, we evaluated the value of soluble programmed death-1 (sPD-1), sPD-1 ligand (sPD-L1) and anti-recP29 antibody concentrations, as predictors of early surgical treatment outcome in young CE-affected patients. Methods and results This prospective study included 59 Tunisian children (177 plasmas ), where CE was surgically treated and monitored for 3 post-operative years. Based on CE post-surgical development, patients were clustered into a "No relapsed" CE (NRCE; n = 39) and a "Relapsed" CE (RCE; n = 20) group. Serum levels of sPD-1, sPD-L1 and anti-recP29 IgG were measured using ELISA. In the NRCE group, sPD-1, sPD-L1 and anti-recP29 IgG concentrations were significantly lower at D365 than at D30. By contrast, in the RCE group, no significant difference was observed between D0, D30 and D365.When considering individual variations, the probability to be "relapse-free" was 67% and 73% when anti-recP29 IgG and sPD-L1 level, respectively, decreased between D30 and D365. The probability to be "relapse-free" was 86% when the sPD-1 level decreased between D30 and D365 (p= 0.003; Chi-square test). Conclusion sPD-1 may be a useful biomaker for the early evaluation of surgical procedure efficacy in pediatric CE cases.
- Subjects :
- 0301 basic medicine
Male
sPD-1
Gastroenterology
recP29
B7-H1 Antigen
0302 clinical medicine
MESH: Child
Secondary Prevention
follow-up
MESH: B7-H1 Antigen
Prospective Studies
Surgical treatment
Prospective cohort study
Child
MESH: Treatment Outcome
biology
MESH: Secondary Prevention
MESH: Enzyme-Linked Immunosorbent Assay
3. Good health
cystic echinococcosis
Treatment Outcome
Child, Preschool
Female
Antibody
medicine.medical_specialty
Adolescent
030231 tropical medicine
Immunology
Enzyme-Linked Immunosorbent Assay
Relapse rate
post-surgical outcome
sPD-L1
03 medical and health sciences
MESH: Echinococcosis
children
Echinococcosis
Internal medicine
mental disorders
medicine
Humans
MESH: Adolescent
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health
MESH: Humans
Cystic echinococcosis
Significant difference
MESH: Child, Preschool
MESH: Prospective Studies
MESH: Male
030104 developmental biology
biology.protein
MESH: Biomarkers
Parasitology
Programmed death 1
MESH: Female
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 01419838 and 13653024
- Database :
- OpenAIRE
- Journal :
- Parasite Immunology, Parasite Immunology, Wiley, 2021, 43 (3), pp.e12809. ⟨10.1111/pim.12809⟩
- Accession number :
- edsair.doi.dedup.....25505af28b0589c9c8e538b999623ba5