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Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
- Source :
- Pediatric Nephrology (Berlin, Germany)
- Publisher :
- Springer Nature
-
Abstract
- Glomerular filtration rate (GFR) was evaluated in 32 Wilms' tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m(2) [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m(2) [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m(2) with 99 Tc- DTPA.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Adolescent
99 Tc-DTPA
Urology
Renal function
Antineoplastic Agents
Urine
Wilms’ tumour survivors
urologic and male genital diseases
Wilms Tumor
Excretion
Young Adult
Internal medicine
Prevalence
CKD
medicine
Humans
Survivors
Pediatrics, Perinatology, and Child Health
Renal Insufficiency, Chronic
Cystatin C
Child
Ultrasonography
Kidney
Radiotherapy
biology
business.industry
eGFR formulas
medicine.disease
Kidney Neoplasms
female genital diseases and pregnancy complications
Cross-Sectional Studies
Endocrinology
medicine.anatomical_structure
Blood pressure
Child, Preschool
Pediatrics, Perinatology and Child Health
biology.protein
Female
Original Article
business
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 26
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....254d772e75a848b398b38adadc472eda
- Full Text :
- https://doi.org/10.1007/s00467-011-1759-3