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Progression and new onset of nonalcoholic fatty liver disease in living kidney donors compared to healthy controls
- Source :
- Clinical Transplantation. 32:e13240
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background There is growing evidence linking nonalcoholic fatty liver disease (NAFLD) with reduced glomerular filtration rate (GFR). Living kidney donors do not have underlying kidney disease, but have reduced GFR as a result of nephrectomy. Whether kidney donation is associated with a higher risk for development or progression of NAFLD is currently unknown. Methods Retrospective evaluation of metabolic parameters and sonographic evidence of NAFLD were performed in 232 living kidney donors and 162 healthy controls. Results A total of 25 donors and 44 controls had NAFLD at baseline. During a mean follow-up of 6.8 years, 6 donors (24%) and 17 controls (38.6%) (P = .29) had a remission of NAFLD, related with decreased body mass index (BMI). The progression of NAFLD fibrosis score was similar in both groups. New onset of NAFLD was observed in 14 (6.8%) donors and 13 (11.01%) controls (P = .211), and was related to increased BMI and a higher baseline Fatty Liver Index score. Neither eGFR nor urine albumin excretion in the donors were related to new onset or progression of NAFLD. Conclusions Reduced kidney function secondary to kidney donation is not associated with increased incidence or progression of NAFLD.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Renal function
Kidney Function Tests
Nephrectomy
digestive system
Gastroenterology
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Risk Factors
Internal medicine
Nonalcoholic fatty liver disease
Living Donors
medicine
Humans
030212 general & internal medicine
Age of Onset
Retrospective Studies
Transplantation
Kidney
business.industry
Incidence (epidemiology)
Fatty liver
nutritional and metabolic diseases
Middle Aged
Prognosis
medicine.disease
Kidney Transplantation
digestive system diseases
medicine.anatomical_structure
Case-Control Studies
Disease Progression
Female
030211 gastroenterology & hepatology
Metabolic syndrome
business
Follow-Up Studies
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 09020063
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....253fa3f16315d696091096856b8db759